This page has the numbers for lettuce: 8 inches between plants with 12 inches between rows, four to a square foot, direct sown four weeks before your last frost or transplanted three weeks before it, an inch of water a week, and half a pound to a pound per plant in 45 to 65 days.
The numbers matter less here than the calendar. Lettuce bolts in heat, so the page is mostly about sowing a short row every two or three weeks rather than one long row in April, and about when to stop and start again in late summer.
Sowing
Lettuce seed germinates at surprisingly low temperatures and refuses at high ones, which shapes everything about how it is grown. Direct sow from about four weeks before your last frost date, or start indoors six weeks before and transplant three weeks before the frost date — the seedlings take a light frost without complaint.
Sow shallowly. Lettuce needs light to germinate, so press the seed into the surface and cover it barely or not at all. Sowing too deep is the usual reason a row fails to come up.
In midsummer, germination becomes the problem rather than bolting. Seed sown into warm soil may not come up at all. Sowing in the late afternoon, watering the drill before sowing, and shading the row all help.
Spacing and thinning
Eight inches between plants with 12 inches between rows suits a full head. For cut-and-come-again leaves you can sow much thicker and simply cut across the row.
Thin early and thin properly. Lettuce left crowded makes small, floppy plants that bolt sooner, and the thinnings are the best salad of the season. Four plants per square foot is the square-foot-gardening figure and it is about right.
Water and food
An inch of water a week, and more importantly, without long dry gaps. Lettuce is shallow rooted and mostly water, so it feels a dry spell within days. Bitterness and bolting both follow drought stress.
Feeding is straightforward: nitrogen for leaf growth, given lightly and often rather than in one dose. Compost worked into the bed before sowing is usually enough for a crop this quick. Lettuce is a good candidate for the space between slower crops — a row of lettuce between young brassicas will be finished before the brassicas need the room.
Succession, the part that matters
The difference between a gardener who has salad all season and one who has a glut in June is entirely a matter of sowing little and often. A three-foot row every two or three weeks, through spring and then again from late summer, keeps a household in leaves without any of it going to seed uneaten.
Stop sowing through the hottest weeks and start again as nights begin to cool. Autumn lettuce is often the best of the year: the plants grow steadily, nothing bolts, and pests have mostly finished.
Common trouble
Slugs are the main enemy, particularly on seedlings in damp spring weather. Going out after dark with a torch is unglamorous and more effective than most alternatives.
Aphids collect in the heart of a plant where they are hard to wash out, which is an argument for picking outer leaves rather than whole heads late in the season.
Tip burn — brown, crisped leaf edges — comes from irregular water in hot weather rather than from disease. Mulch and consistency are the answer.